Effects of artemisinin and TSP-1-human endometrial-derived stem cells on a streptozocin-induced model of Alzheimer’s disease and diabetes in Wistar rats

Alzheimer’s disease (AD) is an age-associated dementia disorder characterized by A? plaques and neurofibrillary tangles. There a strong link between cerebrovascular angiopathy, oxidative stress, inflammation, glucose metabolism abnormalities with the development of AD. In this study, we investigated therapeutic influences artemisinin TSP-1-human endometrial-derived stem cells (TSP-1-hEDSCs) on streptozocin-induced model AD diabetes in rats. Hippocampal intraperitoneal injections streptozocin were used to induce male Wistar rats, followed intranasal administration single dose TSP-1-hEDSCs for 4 weeks. Hematoxylin together eosin staining was performed demonstrating plaque formation analyzing influence treatments pyramidal hippocampus. Biochemical analysis assay serum levels glucose, MDA, ROS, TAC. The expression TNF-? measured using real-time PCR. Streptozocin induced via increasing blood levels. It also increased decreased Simultaneous or separate ameliorated considerably reducing hippocampus, levels, TAC appears that improve adverse features rat diabetes. Therefore, could be utilized as adjunct treatment, well protective agent, patients.